The first suggestions to establish a university in Mashhad refers back to 1934 the same time as Tehran University was established. After years of attempts, considering the dire need to have doctors in Khorasan Province, in 1947 government cabinet consented to establish a university in Mashhad. Its constitution was also ratified then. Finally, in November 23rd 1949, the university was officially inaugurated by Late Dr. Zangeneh, the Minister of Culture at that time. It was recognized as the first Scientific Medical Center with 61 students. The faculty members were comprised of one associate professor and seven instructors. Imam Reza Hospital is an affiliated hospital to Mashhad University of Medical Sciences and is the biggest hospital in Mashhad with a 90 year history. The building project started in 1928 in an area of 28.5 Hectares with 28,500 square meter infrastructure. In 1934, the hospital started to work with the name of Shah Reza Hospital. In 1975, under an agreement, Astan Quds (the administrative organization of Imam Reza’s Shrine) attempted to prepare a 90 year transfer protocol according to which the hospital contract was transferred to Mashhad University of Medical Sciences. Since then, the hospital is working as an educational treatment center under the supervision of the university. In addition to meeting health and treatment requirements in the society and extending the related facilities, Mashhad University of Medical Sciences is also in charge of education; therefore, there are diligent attempts with utmost strength taking advantage of facilities and available options to fulfill all purposes mentioned above. Having seven schools including: Medical school, Dentistry, Pharmacy, Traditional Persian Medicine, Nursing and Midwifery, Hygiene and Paramedical Sciences, this university plays a crucial role in training efficient and committed human resources for the country. At the moment, with more than 8,500 students in different degree programs, it is recognized as the main university and east headquarter of the country.